4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine - Names and Identifiers

Name	4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine
Synonyms	4-chloro-2 4-chloro-1H,2H,3H-pyrrolo[3,2-c]pyridine 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine 4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine 1H-Pyrrolo[3,2-c]pyridine, 4-chloro-2,3-dihydro- 1H-pyrrolo[3,2-c]pyridine, 4-chloro-2,3-dihydro- 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine HCl 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride
CAS	494767-29-2
InChI	InChI=1/C7H7ClN2/c8-7-5-1-3-9-6(5)2-4-10-7/h2,4,9H,1,3H2

4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine - Physico-chemical Properties

Molecular Formula	C7H7ClN2
Molar Mass	154.6
Density	1.291±0.06 g/cm3(Predicted)
Boling Point	298.1±40.0 °C(Predicted)
Flash Point	134.1°C
Vapor Presure	0.00129mmHg at 25°C
pKa	4.49±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.585

4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine - Introduction

4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is an organic compound with the chemical formula C9H7ClN and a molecular weight of 175.61g/mol. It is a pale yellow to yellow solid and has the following properties:

1. melting point: about 125-127 ℃
2. Boiling point: about 336 ℃ (decomposition)
3. Solubility: Slightly soluble in water, soluble in organic solvents such as methanol, ethanol and chloroform

4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine has a wide range of applications in the field of medicine. It is an important intermediate compound that can be used in the synthesis of various drugs, especially anti-tumor and anti-inflammatory drugs. In addition, it can also be used to prepare organic photoelectric materials and dyes.

Methods for preparing 4-Chloro-2, 3-dihydro-1H-chrrolo [3,2-c]pyridine mainly include the following:

1. Chlorination reaction of pyrrolo [3,2-C] pyridine: pyrrolo [3,2-C] pyridine and thionyl chloride are heated together to react to produce 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine.
2. nitration reaction of pyrrolo [3,2-C] pyridine: pyrrolo [3,2-C] pyridine reacts with concentrated nitric acid and concentrated sulfuric acid to generate nitro compounds, which are then reduced to generate 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine.

It should be noted that 4-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine need to comply with safe operating regulations during use. It can cause irritation to the skin and eyes, so wear appropriate protective equipment such as lab gloves and goggles. Avoid inhaling dust or vapor during operation and maintain good ventilation conditions. During storage, it should be kept in a dry, cool place, and away from flammable and oxidizing agents.

Last Update：2024-04-09 20:52:54